生酮饮食在帕金森病领域的研究进展
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1.河南中医药大学第一附属医院脑病科;2.河南中医药大学第一附属医院

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]:国家自然科学(NO.81973618,81503422) ,河南省中医药科学研究专项课题(2022JDZX090);S河南省自然科学(NO.202300410399).


Research progress of the ketogenic diet in the field of Parkinson"s disease
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encephalopathy department, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine

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    摘要:

    生酮饮食(ketogenic diet,KD)是指一种饮食模式,旨在促进个体达到低卡路里含量、最低碳水化合物摄入量、高脂肪消耗和标准蛋白质水平。生酮饮食在临床实践应用治疗包括心脏病、糖尿病、肥胖、自闭症、胶质母细胞瘤和其他癌症等。然而,除了癫痫,生酮饮食尚未被推荐用于任何神经系统疾病。近年来随着对生酮饮食的深入研究,越来越多证据证明,生酮饮食对帕金森病具有神经保护作用,是治疗帕金森病的饮食新疗法。在本综述中,我们详细论述生酮饮食在帕金森病中不同机制的神经保护作用,旨在对本领域的临床和实验研究提供一定的参考。

    Abstract:

    A ketogenic diet refers to an eating pattern designed to promote individuals to achieve a low-calorie content, minimum carbohydrate intake, high-fat consumption, and standard protein levels. The ketogenic diet is used in clinical practice to treat applications including heart dis-ease, diabetes, obesity, autism, glioblastoma, and other cancers. However, the ketogenic diet has not been recommended for any neurological disorder except epilepsy. With the intensive research on the ketogenic diet in recent years, more and more evidence has proved that the ketogenic diet has a neuroprotective effect on Parkinson's disease, and it is a new dietary ther-apy for the treatment of Parkinson's disease. In this review, we discuss in detail the neuropro-tective effects of the ketogenic diet in Parkinson's disease by different mechanisms, aiming to provide some references for clinical and experimental studies in this field.

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  • 收稿日期:2024-07-01
  • 最后修改日期:2024-08-14
  • 录用日期:2024-10-30
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