星形胶质细胞在创伤性脑损伤中的作用及治疗策略
DOI:
作者:
作者单位:

昆明医科大学法医学院法医学系

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


The role of astrocytes in traumatic brain injury and therapeutic strategies
Author:
Affiliation:

School of Forensic Science,Kunming Medical University

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    创伤性脑损伤(traumatic brain injury,TBI)是由外力因素直接或间接作用引起的脑组织结构或功能缺失的损伤。星形胶质细胞(Astrocyte, AS)作为中枢神经系统的稳态细胞,在TBI早期阶段迅速增殖、活化,参与损伤后的神经炎症、血脑屏障破坏、胶质瘢痕形成、兴奋性毒性等一系列病理过程,在TBI的继发性神经损伤中扮演了至关重要的角色。本文综述了星形胶质细胞在TBI损伤修复过程中的作用,并以星形胶质细胞为靶向药物的研究进展,旨在为TBI的预防和治疗提供新策略。

    Abstract:

    Traumatic brain injury (TBI) is an injury caused by the direct or indirect effects of external factors that result in structural or functional loss of brain tissue. Astrocytes, as homeostatic cells of the central nervous system, proliferate and activate rapidly in the early stages of TBI, and participate in a series of pathological processes such as neuroinflammation, blood-brain barrier disruption, glial scarring, and excitotoxicity after injury, and play a crucial role in the secondary neurological injury of TBI. This paper reviews the role of astrocytes in the repair of TBI damage with the aim of providing new strategies for the prevention and treatment of TBI.Traumatic brain injury (TBI) is a kind of craniocerebral injurious disease caused by external force that results in structural destruction of brain tissue and physiological dysfunction, with high morbidity, high disability, high mortality and high treatment burden, for which there has not yet been an effective therapeutic measure. Astrocytes, as homeostatic cells of the central nervous system, are rapidly proliferated and activated in the early stages of TBI to participate in a series of pathological processes such as neuroinflammation, blood-brain barrier disruption, glial scarring, excitotoxicity and other pathological processes after injury, and play a crucial role in the secondary neurological injury of TBI. The article focuses on the role of astrocytes in the pathological damage of TBI and reviews the research progress of astrocyte-targeted drugs, aiming to provide new strategies for the prevention and treatment of TBI.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2024-06-03
  • 最后修改日期:2024-07-23
  • 录用日期:2024-10-30
  • 在线发布日期:
  • 出版日期:
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭