山医群体近交系自发性2型糖尿病中国地鼠血液生理生化指标的检测分析
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山西医科大学

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Measurement and Comparative Analysis of Blood Physiological and Biochemical Indexes of Spontaneous Type 2 Diabetes Chinese Hamster in the SHANXI MU Colony
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Shanxi Medical University

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    目的:探究课题组前期建立的山医群体近交系中国地鼠自发性2型糖尿病(T2DM)动物模型的血液生理生化变化情况。方法:选取12月龄山医群体近交系自发性T2DM中国地鼠及正常地鼠各10只,进行空腹采血,应用Sysmex XT自动血液分析仪及Hitachi全自动生化仪对血液15项生理指标及16项生化指标进行测定并进行统计分析。结果:与正常对照组相比,糖尿病组白细胞(WBC)、红细胞(RBC)、血小板(PLT)、血红蛋白浓度(HGB)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血糖(GLU)、总胆固醇(TC)、甘油三酯(TG)、尿酸(UA)等指标具有统计学差异(P < 0.05)。结论:对课题组前期建立的山医群体近交系中国地鼠自发性T2DM模型进行血液生理生化指标检测分析,其变化符合人类T2DM发病的趋势,为该模型的应用及发展提供了基础数据。

    Abstract:

    Objective: Investigate the blood physiological and biochemical changes in the spontaneously developed type 2 diabetes mellitus (T2DM) animal model of the SHANXI MU colony inbred strain established by the research team in the preliminary stage. Methods: A cohort of spontaneously developed T2DM Chinese hamsters and normal hamsters, each comprising 10 individuals at 12 months of age, were selected for the study. Fasting blood samples were collected and analyzed using the Sysmex XT automated hematology analyzer and the Hitachi fully automatic biochemical analyzer to measure and statistically analyze 15 physiological parameters and 16 biochemical indicators in the blood. Results: Compared with the control group, WBC, RBC, PLT, HGB, ALT, AST, GLU, TC, TG and UA in diabetic group were significantly different(P < 0.05). Conclusion: The blood physiological and biochemical indexes of the Chinese hamster spontaneous T2DM model established by the research group in the early stage were detected, and the changes were in line with the trend of human T2DM incidence, which provided basic data for the application and application of the model.

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  • 收稿日期:2024-04-17
  • 最后修改日期:2024-04-26
  • 录用日期:2024-05-14
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