中医外治法调控类风湿关节炎相关通路研究进展
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1.贵州医科大学;2.贵州医科大学附属医院

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吕明庄全国名老中医药专家传承工作室织金工作站


Progress in the study of the regulation of rheumatoid arthritis-related pathways by external treatment of traditional Chinese medicine
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1.Guizhou Medical University;2.Affiliated Hospital of Guizhou Medical University

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    摘要:

    类风湿关节炎(rheumatoid arthritis,RA)是一种自身免疫性疾病,常以对称性小关节疼痛为早期临床表现,迁延难愈逐渐加重,常常累及多个关节最终造成关节炎畸形,使患者失去劳动能力。分子信号通路一直以来都是研究RA防治的关注焦点,研究发现RA病程发生发展与Janus激酶-信号转导与转录激活因子(JAK-STAT)信号通路、丝裂原活化蛋白激酶(MAPKs)信号通路、核因子κB(NF-κB)信号通路、NOD样受体蛋白3(NLRP3)信号通路、Toll样受体(TLRs)信号通路、Wnt信号通路、Notch信号通路、缺氧诱导因子1-α与血管内皮生长因子(HIF-1α/VEGF)信号通路、程序性死亡因子1与配体1(PD-1/PD-L1)信号通路、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)/哺乳动物雷帕霉素靶蛋白(mTOR)信号通路均有密切联系。近些年来中医外治法基于以上信号通路治疗RA的研究逐渐增多,逐步深入。本文通过查阅相关资料与报道,阐述以上通路与RA发病、防治的关系,并总结中医外治法调控以上信号通路防治类风湿性关节的研究成果,以期为临床选用中医外治法为治疗选择提供科学依据。

    Abstract:

    Rheumatoid arthritis (RA) is an autoimmune disease with symmetric small joints pain as an early clinical manifestation, which gradually worsens and often involves multiple joints, ultimately resulting in arthritic deformities and loss of labor capacity. Molecular signaling pathways have always been the focus of research on the prevention and treatment of RA. Studies have found that the progression of RA disease is closely related to a variety of signaling pathways which include the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway, mitogen-activated protein kinases (MAPKs) signaling pathway, the NOD-like receptor protein 3 (NLRP3) signaling pathway, the toll-like receptors (TLRs) signaling pathway, the Wnt signaling pathway, Notch signaling pathway, hypoxia-inducible factor 1-alpha and vascular endothelial growth factor (HIF-1alpha/VEGF) signaling pathway, programmed death factor 1 and ligand 1 (PD-1/PD-L1) signaling pathway and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway. In recent years, the studies on the treatment of RA with external treatment of traditional Chinese medicine based on the above signaling pathways have gradually increased and deepened. In this paper, we reviewed the relevant data and reports to explain the relationship between the above pathways and the pathogenesis and prevention of RA and summarized the research results on the modulation of the above signaling pathways by external treatment of traditional Chinese medicine to prevent and treat rheumatoid joints with a view to providing a scientific basis for the clinical selection of this treatment.

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  • 收稿日期:2024-04-11
  • 最后修改日期:2024-08-12
  • 录用日期:2024-09-30
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