巴戟天寡糖对抑郁症改善作用的研究进展
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北京联合大学生物活性物质与功能食品北京市重点实验室

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Research progress on the improvement effect of Morinda officinalis oligosaccharides on depression
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Beijing Key Laboratory of Bioactive Substances and Functional Food,Beijing Union University

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    摘要:

    抑郁症是一种心理精神障碍疾病。近些年,全世界抑郁症发病率的不断升高,给社会带来沉重的经济负担。巴戟天寡糖是从中草药巴戟天中提取的活性物质,可以舒郁安神、补肾益智,还可以通过调节单胺类神经递质水平、增强神经可塑性、调节HPA轴、调节细胞因子水平抗抑郁,同时对患者的认知障碍有一定的改善作用。本文基于抑郁症的发病假说,总结了巴戟天寡糖在抗抑郁方面的作用,为巴戟天寡糖抗抑郁药物研发提供理论依据。

    Abstract:

    Depression is a psychosomatic disorder. In recent years, the rising incidence of depression around the world, bringing a heavy economic burden on society. The active substances extracted from the Chinese herb Morinda officinalis can soothe depression and calm the mind, tonify the kidney and benefit the intellect, and can also regulate monoamine neurotransmitter levels, enhance neuroplasticity, regulate the HPA axis, and regulate cytokine levels in antidepressant, as well as improve cognitive disorders in patients to a certain extent. Based on the hypothesis of the pathogenesis of depression, this paper summarises the role of Morinda officinalis oligosaccharides in antidepressant, and provides theoretical basis for the research and development of Morinda officinalis oligosaccharides antidepressant drugs.

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  • 收稿日期:2024-03-25
  • 最后修改日期:2024-05-31
  • 录用日期:2024-08-26
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