动物生物安全三级模拟实验室的建设与实践探讨
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1.中国疾病预防控制中心;2.新疆医科大学第一附属医院临床医学研究院;3.四川省疾病预防控制中心

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] 国家重点研发计划(2022YFC2304302)


Analysis on the Construction and Practice of Animal Biosafety Level-3(ABSL-3)Simulated Laboratory
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1.Chinese Center for Disease Control and Prevention;2.Clinical Medicine Institute, The First Affiliated Hospital of Xinjiang Medical University;3.Sichuan Center for Diseases Control and prevention

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    摘要:

    动物生物安全三级实验室(ABSL-3)是可以开展高致病性病原微生物感染实验动物的生物安全防护水平为三级的高级别生物安全实验室。近年来随着新发、再发传染病的不断出现,高级别生物安全实验室在病原致病机理、药物和疫苗研发等方面发挥了越来越重要的硬件支撑作用,ABSL-3实验室的需求与日俱增,与此同时,对于能够胜任ABSL-3实验室工作的人员需求也越来越多,岗前培训的系统化、规范化、标准化成为进入ABSL-3实验室开展工作的人员降低风险的重要保证。高级别生物安全实验室的岗前培训工作需要在特定的场所——模拟实验室内开展,因此有必要建立动物生物安全三级模拟实验室(ABSL-3模拟实验室),并建立科学有效的运行标准和机制。本文全面介绍了ABSL-3模拟实验室的设计、建设、运行及作用。

    Abstract:

    ABSL-3 laboratory is Animal Biosafety Level-3 laboratory where highly pathogenic microorganisms can be done. In recent years, with the continuous emergence of emerging and re-emerging infectious diseases, high-level biosafety laboratories have played an increasingly important role in the hardware support of pathogenic mechanism, drug and vaccine research and development. The demand for ABSL-3 laboratories is increasing year by year. At the same time, there is also an increasing demand for personnel competence of working in ABSL-3 laboratories. The standardization of pre-service training has become an important guarantee to reduce the risk of personnel working in the ABSL-3 laboratory. The systematized, normalized and standardized training work needs to be carried out in a specific place. Simulated laboratory is the best place. Therefore, it is necessary to establish animal biosafety level-3 simulated laboratory and establish scientific and effective operating standards and mechanisms. This paper introduces the design, construction, operation and function of ABSL-3 simulated laboratory.

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  • 收稿日期:2024-02-27
  • 最后修改日期:2024-04-24
  • 录用日期:2024-05-14
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