SHP2在消化系统肿瘤中的研究进展
DOI:
作者:
作者单位:

1.河北北方学院;2.河北北方学院附属第一医院普通外科;3.河北北方学院附属第一医院

作者简介:

通讯作者:

中图分类号:

R735.3????????????????????????????????????

基金项目:

2022年河北省省自然科学精准医学联合(编号:H2022405033)


Research progress of SHP2 in digestive system tumors
Author:
Affiliation:

1.Hebei North University,Zhangjiakou,Hebei Province;2.Department of General Surgery,The First Affiliated Hospital of Hebei North University,Zhangjiakou,Hebei Province;3.Department of General Surgery, The First Affiliated Hospital of Hebei North University

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    【摘要】 目前恶性肿瘤已经成为威胁人类身体健康的主要疾病之一,致残率、致死率在逐年上升。Src同源性2的蛋白酪氨酸磷酸酶2(SHP2)是PTP家族中重要的一员,是一种功能广泛的酪氨酸磷酸酶,其在多种实体肿瘤中的表达量升高,在侵袭、转移、增殖、凋亡、耐药性等方面发挥着重要调控作用。已有大量研究表明,SHP2在许多实体瘤的发生和发展中起着非常重要的作用,但现在尚无系统的报道SHP2在消化系统肿瘤中的作用。基于此该文综述了SHP2在7种消化系统中不同肿瘤的生物学功能及临床意义,探讨其在不同癌症发展阶段的作用与机制,并总结与展望SHP2抑制剂的发展,进一步寻找有效的早期诊断和基因治疗的潜在靶点,这对癌症患者生存率的提高具有十分重要的意义。

    Abstract:

    【Abstract】 Currently malignant tumors have become one of the major diseases threatening human health,with disability and mortality rates increasing year by year.Protein tyrosine phosphatase 2 (SHP2) of Src homology 2, an important member of the PTP family, is a tyrosine phosphatase with a wide range of functions,whose expression is elevated in a wide range of solid tumors,and plays a important regulatory role in invasion,metastasis,proliferation,apoptosis and drug resistance.A large number of studies have shown that SHP2 plays a very important role in the genesis and development of many solid tumors,but there is no systematic report on the role of SHP2 in digestive system tumors.Based on this paper,we reviewed the biological functions and clinical significance of SHP2 in seven different tumors of the digestive system,explored its roles and mechanisms in different cancer development stages,and summarized and looked forward to the development of SHP2 inhibitors,to further search for potential targets for effective early diagnosis and gene therapy,which is of great significance for the improvement of cancer patients' survival rate.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2023-09-06
  • 最后修改日期:2023-12-02
  • 录用日期:2024-02-21
  • 在线发布日期:
  • 出版日期:
自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
关闭