AMPK:多样性调控机制与疾病治疗新视角
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大理大学

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云南省地方高校联合专项面上项目


AMPK: Diverse Regulatory Mechanisms and New Perspectives for Disease Treatment
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1.大理大学;2.Dali University

Fund Project:

Joint Special Top-level Project of Local Universities in Yunnan Province

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    摘要:

    单磷酸腺苷激活的蛋白激酶(the AMP-activated protein kinase, AMPK)是一种保守的细胞能量感受器,在调控细胞生长、增殖、分化、自噬、磷酸化、串扰以及葡萄糖和脂质代谢等方面起着重要作用,当机体能量匮乏或某些极端情况时AMPK被激活,而在营养过剩时被抑制,以维持能量平衡。此外,AMPK信号通路还介导铁死亡发生的调控机制也体现了其独特作用,AMPK在不同细胞器里发挥特殊调控功能为疾病治疗提供了新的方向。这也是预防疾病的治疗靶标,如生殖系统疾病、衰老、癌症、炎症和心脏功能障碍等。该文综述了细胞能量不平衡对机体微环境造成的损害,AMPK通过多样性信号调控机制激发了其在疾病和药物中的潜在治疗潜力,为不同系统疾病提供了治疗新思路。通过综述AMPK信号通路的多样性调节机制,为靶向AMPK的癌症治疗和其他疾病的治疗提供理论参考。

    Abstract:

    The AMP-activated protein kinase (AMPK) is a conserved cellular energy Adenosine monophosphate, plays an important role in regulating cell growth, proliferation, differentiation, autophagy, phosphorylation, crosstalk, and glucose and lipid metabolism. AMPK is activated when the body is low in energy or under certain extreme conditions, and it's suppressed when there's an excess of nutrients to maintain the energy balance. In addition, the regulatory mechanism of AMPK signaling pathway mediating ferroptosis also reflects its unique role. AMPK plays a special regulatory function in different organelles, which provides a new direction for disease therapy. It is also a therapeutic target for the prevention of diseases such as reproductive system diseases, aging, cancer, inflammation and cardiac dysfunction. This article reviews the damage of cellular energy imbalance to the body's microenvironment. AMPK stimulates its potential therapeutic potential in diseases and drugs through diverse signal regulatory mechanisms, it provides a new way of treatment for different system diseases. This review summarizes the diverse regulatory mechanisms of AMPK signaling pathway, and provides theoretical reference for cancer therapy and other diseases therapy targeting AMPK.

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  • 收稿日期:2023-07-18
  • 最后修改日期:2024-01-09
  • 录用日期:2024-01-26
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自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
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