CAV1在消化道肿瘤中的研究进展
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甘肃中医药大学

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Advances in the study of CAV1 in digestive tract tumors
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Gansu University of Traditional Chinese Medicine

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    摘要:

    【摘要】消化道肿瘤是目前全球最常见的癌症之一,包括食管癌、胃癌、肝癌、胰腺癌和结直肠癌等,其预后不佳,治疗方法仍需进一步改进。小窝蛋白-1(caveolin-1,CAV1)在消化道肿瘤中具有双重调节作用,既是肿瘤抑制因子又是致癌因子。CAV1对消化道肿瘤的细胞增殖、侵袭、转移、血管生成和药物耐受性等方面具有重要作用,调节CAV1蛋白及其相关信号通路可能成为治疗消化道肿瘤的策略之一。因此,本综述就CAV1的结构、功能、表达调控以及调节消化道肿瘤上皮-间充质转换(epithelial-mesenchymal transition,EMT)及其耐药性等方面分析CAV1与消化道肿瘤的关系,以期为临床消化道肿瘤的诊疗提供新的思路。

    Abstract:

    [Abstract] Digestive tract tumour is currently one of the most common types of cancer in the world, including esophageal cancer, gastric cancer, hepatocellular carcinoma, pancreatic cancer and colorectal cancer, etc. Their prognosis is not good and the treatment still needs further improvement. Caveolin-1(CAV1)has a dual regulatory effect in digestive tract tumors, which is both a tumor suppressor and a carcinogen. CAV1 plays an important role in cell proliferation, invasion, metastasis, angiogenesis and drug tolerance of digestive tract tumors, the regulation of CAV1 protein and its related signaling pathways may become one of the strategies for the treatment of digestive tract tumors. Therefore, the review analyzes the relationship between CAV1 and digestive tract tumors in terms of structure, function, expression regulation, regulation of epithelial-mesenchymal transition(EMT)and drug resistance in digestive tract tumors in order to provide new ideas for the diagnosis and treatment of clinical digestive tract tumors.

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  • 收稿日期:2023-07-13
  • 最后修改日期:2023-07-27
  • 录用日期:2024-03-07
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