AIM在炎症反应和脂质代谢疾病中的作用
DOI:
作者:
作者单位:

华北理工大学

作者简介:

通讯作者:

中图分类号:

基金项目:

河北省自然科学基金项目;河北省中医药管理局科技计划项目;唐山市科技计划项目


The effect of AIM in inflammatory reaction and lipid metabolism diseases
Author:
Affiliation:

1.华北理工大学;2.North China University of Science and Technology

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    巨噬细胞凋亡抑制因子(apoptosis inhibitor of macrophage, AIM),是清道夫受体富含半胱氨酸残基超家族(scavenger receptor cysteine rich-super family, SRCR-SF)B组的成员之一。AIM为巨噬细胞分泌的一种可溶性蛋白,该蛋白的表达受肝X受体(liver X receptor, LXR)控制,且在机体的免疫反应中起重要作用。AIM作为巨噬细胞的一种分泌蛋白,发挥着广泛的作用,不仅对巨噬细胞的凋亡具有抑制作用,并且可参与调控巨噬细胞极化。还有相关研究发现,AIM参与炎症、肥胖、动脉粥样硬化和癌症等多种生理、病理过程;可以作为结核病和肝硬化等疾病的生物诊断标志物;可以通过抑制脂肪酸合成酶(fatty acid synthase, FAS)活性从而促进脂肪细胞的脂解,在调节脂质内稳态平衡、脂质代谢与自身免疫疾病中发挥着重要的作用。该文综述了AIM的分子特征及其在炎症反应和脂质代谢等相关疾病方面的作用,展示AIM的多种功能特点,为相关的医学研究提供依据。

    Abstract:

    Apoptosis inhibitor of macrophage (AIM), belongs to the group B of scavenger receptor cysteine rich-super family (SRCR-SF). AIM is a soluble protein secreted by macrophages. The expression of this protein is controlled by the liver X receptor (LXR), and it plays an important role in the immune response of the body. AIM, as a secreted protein of macrophages, plays a broad role. It not only inhibits the apoptosis of macrophages, but also participates in the regulation of macrophage polarization. In addition, relevant studies have revealed that AIM is involved in various physiological and pathological processes such as inflammation, obesity, atherosclerosis and cancer; It was used as a biological diagnosis marker for diseases such as tuberculosis, liver cirrhosis and the like; Besides, it can promote lipolysis of adipose cells by inhibiting the activity of fatty acid synthase (FAS), playing an important role in the regulation of lipid homeostasis, lipid metabolism and autoimmune diseases. In this paper, we reviewed the molecular characteristics of AIM and its effects on inflammation, lipid metabolism and other related diseases, showing multiple functional characteristics of AIM to provide the basis for relevant medical research.

    参考文献
    相似文献
    引证文献
引用本文
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2023-06-26
  • 最后修改日期:2023-08-08
  • 录用日期:2024-02-26
  • 在线发布日期:
  • 出版日期:
自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
关闭