自噬与神经系统疾病
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作者单位:

1.南方医科大学中医药学院;2.南方医科大学中医药学院、南方医科大学南方医院

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基金项目:

国家自然科学基金项目、广东省自然科学基金项目


Autophagy and Neurological Diseases
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Affiliation:

1.School of Traditional Chinese Medicine, Southern Medical University;2.School of Traditional Chinese Medicine, Southern Medical University、Nanfang Hospital, Southern Medical University

Fund Project:

The National Natural Science Foundation of China 、The Natural Science Foundation of Guangdong Province

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    摘要:

    自噬是细胞内异常聚集蛋白和受损细胞器主要的降解和循环途径,维持着细胞正常的代谢平衡及物质更新。自噬具有神经保护作用,可通过调节神经元和胶质细胞的稳态、发育和凋亡等生理过程影响着神经系统的功能状态。近年来大量研究表明,神经系统疾病与异常自噬有着密切的关系,自噬的抑制或过度激活均影响着抑郁症、神经退行性疾病和精神分裂症的发生发展。了解自噬在神经系统疾病中的作用机制对于预防与治疗相关疾病具有重要意义。该文主要对当前自噬与上述神经系统疾病的研究进展进行综述,以期为以上疾病的进一步研究提供参考。

    Abstract:

    Autophagy is the main degradation and recycling pathway of abnormal aggregates and damaged organelles in cells, which maintain the normal metabolic balance and material renewal of cells. Autophagy has neuroprotective effects and can affect the functional state of the nervous system by regulating the homeostasis, development, apoptosis and other physiological processes of neurons and glial cells. In recent years, a large number of studies have shown that nervous system diseases are closely related to abnormal autophagy, and inhibition or overactivation of autophagy affects the occurrence and development of depression, neurodegenerative diseases and schizophrenia. Understanding the mechanism of autophagy in nervous system diseases is of great significance for the prevention and treatment of related diseases. This review mainly reviews the current research progress of autophagy and the above diseases of nervous system, in order to provide reference for further research of these diseases.

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  • 收稿日期:2023-06-19
  • 最后修改日期:2023-08-25
  • 录用日期:2024-02-26
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