线粒体质量控制在呼吸系统疾病中的研究进展
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河南中医药大学医学院

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Research progress of mitochondrial quality control in respiratory diseases
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School of Medicine, Henan University of Chinese Medicine

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    呼吸系统疾病(肺部炎症、肺纤维化)严重危害人类健康。作为真核细胞特有的细胞器,线粒体不仅在产生能量、生物合成和维持细胞内稳态中具有重要功能,而且作为多样化的信号细胞器,参与炎症、增殖、分化、细胞修复等过程。线粒体质量控制系统包括线粒体生物发生、线粒体动力学和线粒体自噬。研究发现,呼吸系统疾病的某些病理机制如氧化应激、炎症等与线粒体质量控制失调密切相关。因此,本文总结线粒体质量控制失调在呼吸系统疾病(慢性阻塞性肺疾病、肺纤维化、急性肺损伤、哮喘和细菌性肺炎)的研究进展,以期从线粒体的角度寻求呼吸系统疾病防治的新思路。

    Abstract:

    Respiratory diseases (lung inflammation, pulmonary fibrosis) are a serious threat to human health. As organelles unique to eukaryotic cells, mitochondria not only have important functions in energy production, biosynthesis and maintenance of intracellular homeostasis, but also act as diverse signaling organelles involved in inflammation, proliferation, differentiation, cell repair and other processes. The mitochondrial quality control system includes mitochondrial biogenesis, mitochondrial dynamics, and mitochondrial autophagy. It has been found that certain pathological mechanisms of respiratory diseases such as oxidative stress and inflammation are closely related to dysregulation of mitochondrial quality control. Therefore, this paper summarizes the research progress of mitochondrial quality control dysregulation in respiratory diseases (chronic obstructive pulmonary disease, pulmonary fibrosis, acute lung injury, asthma and bacterial pneumonia), in order to seek new ideas for the prevention and treatment of respiratory diseases from the perspective of mitochondria.

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  • 收稿日期:2023-06-06
  • 最后修改日期:2023-08-01
  • 录用日期:2024-03-29
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