新生鼠心肌再生相关调节机制的研究进展
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首都医科大学

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Advances in Research on Mechanisms Related to Myocardial Regeneration in Neonatal Rats
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Capital Medical University

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    心血管疾病是一种危害人类健康的疾病,心肌梗死导致的收缩性心力衰竭是造成死亡的主要原因。既往观点认为,成年哺乳动物心脏中心肌细胞自我增殖更新能力有限,而近年来大量报道指出,哺乳动物在出生早期具备心肌再生的能力,并且其强度足以修复受损的心脏组织。新生鼠心肌再生现象的发现,为探讨影响心肌细胞增殖的相关机制研究提供了理想的动物模型,继而许多能够逆转心肌细胞周期阻滞和促进心肌细胞增殖的调控机制得以揭示。本文基于近几年开展的有关新生鼠心肌再生的研究,综述了影响心肌再生基因表达的因素(ncRNAs、转录因子等)、心肌再生相关信号通路、非心肌细胞(细胞外基质、免疫反应、心外膜等)对心肌再生的调节作用,以期为实现成年哺乳动物心肌损伤后心肌再生提供方向。

    Abstract:

    Cardiovascular disease is a health hazard to humans and systolic heart failure due to myocardial infarction is a major cause of death. It was previously thought that myocardial cells of adult mammalian heart possess a limited ability to proliferate and renew themselves, and that after ischemic injury, a large number of myocardial cells are lost and eventually replaced by non-contractile scar tissue. In contrast, it has been widely reported that mammals have the ability to regenerate myocardium which is restricted to early postnatal life, and that it is strong enough to repair damaged heart tissue. The discovery of myocardial regeneration in neonatal heart has provided an ideal animal model to investigate the mechanisms that affect myocardial cell proliferation, and subsequently many mechanisms that can reverse myocardial cell cycle arrest and promote myocardial cell proliferation have been revealed. In this paper, we review the factors affecting myocardial regeneration gene expression (ncRNAs, transcription factors, etc.), myocardial regeneration-related signaling pathways, and the regulation of myocardial regeneration by non-myocardial cells (extracellular matrix, immune response, epicardium, etc.), so as to provide directions for achieving myocardial regeneration after myocardial injury in adult mammals.

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  • 收稿日期:2023-06-06
  • 最后修改日期:2023-08-21
  • 录用日期:2024-01-26
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