Δ9-四氢大麻酚对血脑屏障作用的研究进展
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昆明医科大学

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Research progress in the effects of Δ9-tetrahydrocannabinol on the blood-brain barrier
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Kunming Medical University

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    大麻素的精神活性是众所周知的,关于大麻素在全世界是否可以用于治疗目的也一直存在争议。而Δ9-四氢大麻酚(tetrahidrocannabinol,THC)作为大麻中最主要的精神活性物质,它的神经作用机制直到最近才被发现,但其作用机理仍未完全明确。血脑屏障(blood-brain barrier,BBB)是保护大脑的关键屏障结构,也是外来物质入脑的第一道防线,THC的亲脂性及与内源性大麻素系统的相互作用使其更加容易对BBB产生作用。本文综述了THC的神经毒理作用,聚焦于THC对BBB的作用与机制,为阐明THC的神经作用机制提供理论依据。

    Abstract:

    The psychoactive properties of cannabinoids are well known, and there has been controversy about whether cannabinoids can be used for therapeutic purposes worldwide.Δ9-tetrahydrocannabinol(tetrahidrocannabinol, THC), the main psychoactive substance in cannabis, its neurological mechanism has not been discovered until recently, and its neurological mechanism of action is still not fully understood. The blood-brain barrier(blood-brain barrier, BBB) is a very important barrier structure to protect the brain and is the first line of defense against foreign substances entering the brain. THC's lipophilic nature and its interaction with the endocannabinoid system make it more likely to act on the BBB. In this paper, we review the neurotoxic effects of THC, focusing on the effect and mechanism of THC on the BBB, and provide a theoretical basis for elucidating the neural mechanism of THC.

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  • 收稿日期:2023-05-31
  • 最后修改日期:2023-07-27
  • 录用日期:2024-02-26
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