Abstract:The research on the mechanism of depression is currently a focus in the field of neuroscience, degeneration of brain plasticity (decrease in volume, structural degradation, and functional disorder of the hippocampus, PFC, CG, etc.) leads to depression. Exercise is an important means of improving depression. Current research has confirmed the important mechanism of improving the volume, structure, and function of the hippocampus, PFC, CG, etc. in this process, but related research results only focus solely on changes in a certain brain volume or connectivity function, lacking a comprehensive understanding Systematic analysis of the mechanism of improving brain plasticity in exercise antidepressant effects. Therefore, this study aims to explore the role of brain plasticity in the occurrence of depression and the improvement of depression through exercise. This helps to comprehensively understand the role of brain plasticity in the occurrence of depression, and will also provide new ideas for exercise intervention in depression.