朱砂根抗肿瘤作用研究进展
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遵义医科大学

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Antitumor mechanism of Ardisia Crenata
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zunyi medical university

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    摘要:

    朱砂根是中国传统中药,属于紫金牛科植物,其主要成分为香豆素类、皂苷类、黄酮类和挥发油等。随着对朱砂根抗肿瘤作用的深入研究,其活性抗癌化合物有岩白菜素,朱砂根皂苷A、B,百两金皂苷A、B,蒽贝素,主要通过诱导肿瘤细胞凋亡、增加肿瘤细胞毒性抑制细胞增殖、抑制肿瘤细胞转移和迁徙等多种途径在口腔癌、鼻咽癌、肝癌、结肠癌、膀胱癌、宫颈癌和白血病等肿瘤中显示出很高的抗肿瘤潜力。然而,朱砂根的抗肿瘤机制临床前实验数据缺乏高质量、多样本、多重复的随机对照试验,临床研究数据缺乏肿瘤预后及药效学和药代动力学相关试验数据,应设计精准研究实验和临床试验进一步探索挖掘朱砂根的药理作用。

    Abstract:

    Ardisia Crenata Radix is a traditional Chinese medicine, which belongs to Myrsinaceae, and its main components are coumarins, saponins, flavonoids and volatile oil. Bergenin, ardisicrenoside A, ardisicrenoside B,ardisiacripin A,ardisiacripin B and embelin are active anticancer compounds with the in-depth study of the anti-tumor effect of Ardisia Crenata Radix. They show high potential in oral cancer, nasopharyngeal carcinoma, liver cancer, colon cancer, bladder cancer, cervical cancer and leukemia mainly through inducing tumor cell apoptosis, increasing tumor cytotoxicity, inhibiting cell proliferation, inhibiting tumor cell metastasis and migration, and inducing cell regulatory enzyme cascade reaction. However, the preclinical experimental data of cinnabar root anti-tumor mechanism are lack of high-quality, multi-sample and multi-repeated randomized controlled trials, and the clinical research data are lack of tumor prognosis, pharmacodynamics and pharmacokinetic data. Accurate research experiments and clinical trials should be designed to further explore the pharmacological effects of mining cinnabar root.

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  • 收稿日期:2023-04-19
  • 最后修改日期:2023-08-07
  • 录用日期:2024-01-05
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