小胶质细胞-星形胶质细胞的交互作用及其介导的神经炎症在阿尔茨海默病中的研究进展
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1.齐齐哈尔医学院;2.齐齐哈尔医学院生理教研室;3.齐齐哈尔医学院解剖教研室

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Progress in microglia-astrocyte interactions and their mediated neuroinflammation in Alzheimer's disease
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1.Qiqihar Medical University;2.Department of Physiology, Qiqihar Medical College;3.Department of Anatomy, Qiqihar Medical College

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    摘要:

    阿尔茨海默病(Alzheimer's disease,AD)是一种侵袭性神经退行性疾病,其发病原因迄今未知。神经炎症是中枢神经系统(CNS)中由小胶质细胞和星形胶质细胞激活的难以自主消退的慢性炎症反应,与多种炎症因子和血脑屏障(BBB)相关联。近年来的研究表明,神经炎症已经成为AD中继β-淀粉样蛋白(Aβ)沉积和神经原纤维缠结(NFTs)后的第三大病理特征。本文就小胶质细胞与星形胶质细胞及其交互作用进行总结与分析,并对小胶质细胞与星形胶质细胞的交互作用在神经炎症和AD中的作用进行整理、讨论。以期为小胶质细胞和星形胶质细胞参与AD神经炎症的病理性改变提供参考。

    Abstract:

    Alzheimer's disease (AD) is an aggressive neurodegenerative disease whose pathogenesis is hitherto unknown. Neuroinflammation is a chronic inflammatory response in the central nervous system (CNS) activated by microglia and astrocytes that is difficult to subside autonomously and is associated with multiple inflammatory factors and the blood-brain barrier (BBB). Recent studies have shown that neuroinflammation has become the third major pathological feature in AD after β-amyloid (Aβ) deposition and neurogenic fiber tangles (NFTs). In this paper, we summarize and analyze microglia and astrocytes and their interaction, and organize and discuss the role of microglia-astrocyte interaction in neuroinflammation and AD. In order to provide a reference for the involvement of microglia and astrocytes in the pathological alterations of neuroinflammation in AD.

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  • 收稿日期:2023-04-14
  • 最后修改日期:2023-09-17
  • 录用日期:2023-11-03
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