鸢尾素及其上下游抗抑郁的研究进展
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天津中医药大学

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Progress in irisin and its upstream and downstream antidepressants
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Tianjin University of Traditional Chinese Medicine

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    抑郁症是主要致残原因之一,对人们带来不利影响。尽管抗抑郁药种类越来越多,但临床上仍不能充分治疗抑郁症,因此,目前仍需要探索新的抑郁机制。鸢尾素对神经系统的有益作用逐渐被阐明,研究发现鸢尾素具有抗抑郁的作用,鸢尾素或将成为治疗抑郁症的新靶点。本研究旨在探讨鸢尾素及其上下游抗抑郁的作用机制,通过查阅现有的研究阐释抑郁症与鸢尾素之间存在的联系,提出SIRT1/PGC-1α介导FNDC5/鸢尾素调控BDNF促进神经发生改善抑郁症的潜在机制,为鸢尾素及其上下游抗抑郁的研究提供新思路。

    Abstract:

    Depression is the main cause of disability, and the adverse effects on people are difficult to eliminate. Despite the increasing number of antidepressants, depression is still not adequately treated clinically, and new mechanisms still need to be explored. As the beneficial effects of irisin on the nervous system are gradually elucidated, studies have found that irisin has an antidepressant effect, and irisin may become a new target for the treatment of depression. This study aims to explore the mechanism of irisin and its upstream and downstream antidepressants, by reviewing the existing studies to explain the link between depression and irisin, propose the potential mechanism of SIRT1 / PGC-1α mediating FNDC5/Irisin to regulate BDNF and promote neurogenesis to improve depression, and provide a new idea for the study of irisin and its upstream and downstream antidepressants.

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  • 收稿日期:2023-03-27
  • 最后修改日期:2023-09-06
  • 录用日期:2023-09-07
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