单细胞转录组技术在神经退行性疾病上的应用研究进展
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1.自贡市脑科学研究院;2.自贡市精神卫生中心

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基金项目:

国家自然科学基金项目(面上项目,重点项目,重大项目)


Application Research Progress of Single-cell RNA-sequencing Technology in Neurodegenerative Diseases
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Affiliation:

1.Zigong Institute of Brain Science;2.自贡市精神卫生中心

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    神经退行性疾病(neurodegenerative diseases, NDs)是一类与中枢神经系统密切相关的精神疾病,以特定神经元群的形态异常和功能进展性丧失为主要特征,神经退行性疾病主要包括阿尔茨海默病(Alzheimer’s disease, AD)、帕金森病(Parkinson’s disease, PD)、肌萎缩侧索硬化症(Amyotrophic lateral sclerosis, ALS)、多发性硬化症(Multiple sclerosis, MS)和亨廷顿病(Huntington’s disease, HD),目前还没有发现直接预防或治愈神经退行性疾病的策略。近年来,单细胞转录组技术(single-cell RNA-sequencing, scRNA-seq)被广泛应用于各种神经退行性疾病研究,并发现神经退行性疾病发病机制与脑中免疫细胞态密切相关,主要涉及线粒体功能、血管生成、炎症和突触传递等生物学过程,诱导性多功能干细胞(induced pluripotent stem cells,iPSC)疗法是治疗神经退行性疾病的潜在方案。本文对单细胞转录组测序技术在各种神经退行性疾病上的研究进行综述,以期对将来神经退行性疾病的预防和治疗提供参考。

    Abstract:

    Neurodegenerative diseases (NDs) are the mental diseases closely related to the central nervous system, characterized by morphological abnormalities and slowly progressive loss of function in specific neuron groups. The main diseases include Alzheimer's disease (AD), Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS), Multiple sclerosis (MS) and Huntington's disease (HD). However, the directly therapies for NDs are not founded. In recent years, single-cell RNA-sequencing (scRNA-seq) technology has been widely used in various neurodegenerative diseases. It has been found that the pathogenesis of NDs are involved in conditions of immune cells and biological processes such as mitochondrial function, angiogenesis, inflammation and synaptic transmission. The antilepsis of induced pluripotent stem cells (iPSC) is a potential treatment for NDs. Ultimately, the application of scRNA-seq technology in various NDs was reviewed in this paper ,and provided reference for the future prevention and treatment of NDs.

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  • 收稿日期:2023-03-15
  • 最后修改日期:2023-05-24
  • 录用日期:2023-12-04
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