针刺干预青光眼动物实验研究报告质量评价
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中国中医科学院眼科医院

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Quality Evaluation for Animal Studies on Acupuncture for Glaucoma
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China Academy of Chinese Medical Sciences Eye Hospital

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    目的 通过SYRCLE动物实验风险评估工具、ARRIVE 2.0指南和GSPC清单评价针刺干预青光眼的动物实验报告质量。方法 计算机检索CNKI、VIP、万方、Sinomed、PubMed、Web of Science、Embase、Cochrane Library等数据库,寻找针刺干预青光眼的动物研究文章。使用SYRCLE工具对纳入研究进行偏倚风险评估,使用ARRIVE 2.0指南和GSPC清单对研究报告质量进行评价,通过 Excel和SPSS软件进行统计分析。结果 最终有30篇文章符合纳入/排除标准被纳入最终的分析,其中SYRCLE工具的10项条目中有6项条目低风险率<50%,非低风险条目主要集中在选择性偏倚、实施偏倚和测量偏倚方面。ARRIVE 2.0指南的22项必备子条目中有12项低风险率<50%;16项推荐子条目中有9项低风险率低于50%。GSPC清单19项子条目中有12项子条目低风险率<50%,随机化、盲法、伦理声明、饲养场所和饲养、动物护理和监测以及方案注册是ARRIVE 2.0指南和GSPC清单的非低风险条目。结论 当前公开发表的针刺干预青光眼动物研究方法学质量和实验报告质量普遍不高,对多个条目的描述尚不完善,可能影响读者对实验结果能否进一步转化为临床研究的判断。建议未来的研究严格按照动物实验偏倚风险工具以及报告指南进行,以提高动物实验的设计、实施和报告,保证实验步骤的可重复性及实验结果的再现性,为结果转化到临床提供可靠的证据。

    Abstract:

    Objective To evaluate the quality of animal studies on acupuncture for glaucoma by the SYRCLE’s risk of bias tool, ARRIVE 2.0 guidelines and GSPC checklist. Methods Databases of CNKI, VIP, Wanfang, Sinomed, PubMed, Web of Science, Embase, and Cochrane Library were conducted to find animal research articles on acupuncture for glaucoma. Risk of bias was assessed for included studies using the SYRCLE’s tool, and the reporting quality was evaluated using the ARRIVE 2.0 guidelines and GSPC checklist, statistical analysis was performed by Excel and SPSS software. Results Thirty articles met the inclusion/exclusion criteria and were included in the final analysis. 6 of the 10 items of the SYRCLE’s tool had a low-risk rate of <50%, and the non-low-risk items focused on selectivity bias, implementation bias, and measurement bias. 12 of the 22 essential sub-items of the ARRIVE 2.0 guidelines had a low-risk rate of <50%; 9 of the 16 recommended sub-items had a low-risk rate of <50%; 12 of the 19 subentries of the GSPC list had a low-risk rate of <50%, and randomization, blinding, thical statement, housing and husbandry, animal care and monitoring, protocol registration were non-low-risk items in the ARRIVE 2.0 guidelines and GSPC list. Conclusion The quality of methodology and experimental reportings in animal studies on acupuncture for glaucoma are generally low, and the descriptions of several items are not yet complete, which affects the readers' judgment on whether the animal studies can be further translated into clinical studies. It is advised to further promote the SYRCLE’s tool and reporting guidelines for animal experiments, to enhance the design, performance, and reporting of animal experiments, ensure the reproducibility of experiments and results, and provide reliable evidence for the translation of results to the clinic.

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  • 收稿日期:2023-03-06
  • 最后修改日期:2023-09-16
  • 录用日期:2023-11-03
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