中医药治疗缺血性卒中的表观遗传学机制
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河南中医药大学

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国家自然科学基金项目(面上项目,重点项目,重大项目)


Research progress of traditional Chinese medicine for stroke based on epigenetic regulation
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Henan University of Traditional Chinese Medicine

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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    表观遗传学是分子生物学的一个分支,是生命科学领域后基因时代的研究热点,应用表观遗传修饰研究方法是缺血性卒中发病机制的前沿领域,是阐释中医药治疗缺血性卒中的靶点及其作用机制的有效途径。目前,缺血性卒中的的病因病机尚未完全明确,现代医学治疗尚有不足,而中医药治疗缺血性卒中具有独特的优势和广阔前景。最新研究发现,中医药能参与调控异常表观遗传修饰治疗中风。本文主要从中风的中医理论的表观遗传学基础以及从DNA甲基化、非编码RNA和组蛋白修饰三个方面在中风治疗及中医药研究中的应用入手,阐释中医药治疗中风的表观遗传作用,以期为该病的中医药治疗提供新思路和科学依据

    Abstract:

    Epigenetics is a branch of molecular biology, and is a research hotspot in the post-gene era in the field of life sciences. The application of epigenetic modification research methods is the frontier field of the pathogenesis of ischemic stroke, and it is the interpretation of traditional Chinese medicine in the treatment of ischemia. Targets of stroke and effective approaches to their mechanisms of action. At present, the etiology and pathogenesis of ischemic stroke has not been fully clarified, and modern medical treatment is still insufficient. The treatment of ischemic stroke with traditional Chinese medicine has unique advantages and broad prospects. The latest research has found that traditional Chinese medicine can participate in the regulation of abnormal epigenetic modification in the treatment of stroke. This article mainly starts from the epigenetic basis of traditional Chinese medicine theory of stroke and the application of DNA methylation, non-coding RNA and histone modification in stroke treatment and traditional Chinese medicine research, and explains the appearance of traditional Chinese medicine in the treatment of stroke. The role of heredity in order to provide new ideas and scientific basis for traditional Chinese medicine treatment of the disease

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  • 收稿日期:2023-02-22
  • 最后修改日期:2023-05-24
  • 录用日期:2023-12-04
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