重度哮喘动物模型构建的研究进展
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上海市针灸经络研究所

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基金项目:

国家自然科学基金项目;国家自然科学基金项目(面上项目,重点项目,重大项目)


Advances in the construction of animal models of severe asthma
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Affiliation:

1.ShanghaiResearchInstituteofAcupunctureandMeridian;2.Shanghai Research Institute of Acupuncture and Meridian

Fund Project:

The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    重度哮喘(severe asthma,SA)患者需要大剂量激素,在联合其他药物治疗才能够维持症状控制,或即使采用上述治疗仍不可控,是目前哮喘临床治疗的难点。建立一种稳定可复制、高度模拟SA患者病理生理和临床特征的实验动物模型,是加深对SA发病机制研究,发现潜在治疗靶点和开发靶向药物的关键基础性环节。本文通过回顾与整理国内外近10年来SA动物模型相关的实验研究,从动物选择、模型制备方法、模型病理表型等方面总结和分析SA动物模型构建的最新进展,为基于动物模型开展的SA基础研究提供参考依据。

    Abstract:

    Severe asthma (SA), which requires high doses of glucocorticoids in combination with other medications to maintain symptom control or is uncontrollable even with these treatments, is currently a challenge in the clinical management of asthma. The establishment of a stable and reproducible experimental animal model that highly mimics the pathophysiological and clinical characteristics of patients with severe asthma is a key fundamental link in deepening the study on the pathogenesis of severe asthma, identifying potential therapeutic targets and developing targeted drugs. This paper reviews the experimental studies related to the construction of animal models of severe asthma in the past 10 years, and summarizes the recent progress in the establishment and evaluation of animal models of severe asthma from three aspects: animal selection, animal model construction protocols, and model pathological phenotypes. To summarize and analyze the latest progress in the construction of SA animal models, and provide a reference for SA basic research based on animal models.

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  • 收稿日期:2023-02-17
  • 最后修改日期:2023-06-26
  • 录用日期:2023-09-05
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