高原对线粒体功能及能量代谢影响研究进展
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1.甘肃中医药大学药学院;2.军事科学院军事医学研究院辐射医学研究所

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后勤科研项目(CLB21J036);拔尖培育项目(2021yxky001);青年培育项目(2021yxky060);甘肃省卫生行业科研计划项目(GSWSKY2020-41)


Research Progresses on the Effects of the Plateau on Mitochondrial Function and Energy Metabolism
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1.College of Pharmacy, Gansu University of Chinese Medicine;2.Institute of Radiation Medicine Sciences,Academy of Military Medical,Academy of Military Sciences

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    摘要:

    高原是一个低压、低氧、高寒的特殊环境,高原环境将降低能量物质代谢与线粒功能从而影响高原作业,近年来,线粒体损伤引起了广泛关注,线粒体作为细胞的能量工厂,与机体运动紧密相关。以高原线粒体损伤为研究核心,通过网络数据库检索总结高原对于基础能量物质的代谢影响以及对线粒体生化供能反应关键酶活性和线粒体结构功能的改变,发现蛋白质、糖类与脂质代谢在高原受到负面影响,导致高原作业时易疲劳、高血脂症与机体修复受阻;丙酮酸代谢、三羧酸循环、β-氧化和氧化磷酸化相关酶活性被抑制,线粒体形态与数目改变,导致线粒体功能受损,影响运动供能。未来高原细胞损伤机制的探明将大力推动高原损伤防治药物的研究。

    Abstract:

    The plateau is a unique environment with low pressure, low oxygen and high cold. The plateau environment will reduce the metabolism of energy substances and mitochondrial work, thus affecting the plateau operation. In recent years, mitochondrial damage has attracted wide attention. As the energy factory of cells, mitochondria are closely linked to the movement of the body. We focused our attention on mitochondrial damage at high altitude, and summarized the effects of high altitude on the metabolism of basic energy substances and the changes of key enzyme activities and mitochondrial structure and function in mitochondrial biochemical energy supply response. It was found that protein, carbohydrate and lipid metabolism was negatively affected at high altitude, resulting in fatigue, hyperlipidemia and body repair. The activities of enzymes related to pyruvate metabolism, tricarboxylic acid cycle, β-oxidation and oxidative phosphorylation are inhibited, and the morphology and number of mitochondria are changed, which will lead to impaired mitochondrial function and affect exercise energy supply. In the future, the exploration of the mechanism of plateau cell injury will vigorously promote the research of plateau injury prevention and treatment drugs.

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  • 收稿日期:2023-02-13
  • 最后修改日期:2023-07-03
  • 录用日期:2023-10-09
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