滋养层细胞在先兆流产合并宫腔积血中的研究进展
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河南中医药大学第一附属医院

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国家自然科学基金项目(面上项目)82074167


Research advances of trophoblast cells in threatened abortion complicated with intrauterine hemorrhage
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Affiliation:

1.河南中医药大学第一附属医院;2.the First Affiliated Hospital of Henan University of CM

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The National Natural Science Foundation of China (General Program)

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    摘要:

    先兆流产合并宫腔积血是妊娠期常见疾病,其发病机制与母胎界面微环境失衡、子宫螺旋动脉重塑受阻有关。滋养层细胞是母胎界面微环境的最外层,其增值、迁移及侵袭与正常妊娠密切相关,在免疫耐受与调节、子宫螺旋动脉重塑、维持母胎界面微环境等方面发挥着不可替代的作用。近年来滋养层细胞已经成为自身免疫性疾病等领域的研究主线,研究发现其在先兆流产合并宫腔积血的诊治中发挥重要作用。本文就滋养层细胞在先兆流产合并宫腔积血中的研究进展进行综述。

    Abstract:

    Threatened abortion complicated with intrauterine hemorrhage is a common disease during pregnancy.Its pathogenesis is related to the imbalance of maternal-fetal interface microenvironment and the obstruction of uterine spiral artery remodeling. Trophoblast cells are the outermost layer of the maternal-fetal interface microenvironment .Its proliferation, migration and invasion are closely related to normal pregnancy.It plays an irreplaceable role in immune tolerance and regulation, uterine spiral artery remodeling, and maintenance of maternal-fetal interface microenvironment.In recent years, trophoblast cells have become the main line of research in autoimmune diseases and other fields.Studies have found that it plays an important role in the diagnosis and treatment of threatened abortion complicated with intrauterine hemorrhage.This article reviews the research progress of trophoblast in the treatment of threatened abortion complicated with intrauterine hemorrhage.

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  • 收稿日期:2022-10-01
  • 最后修改日期:2022-10-20
  • 录用日期:2023-04-22
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