基于中西医临床病症特点的眩晕动物模型分析
作者:
作者单位:

河南中医药大学 药学院,郑州 450046

作者简介:

通讯作者:

中图分类号:

基金项目:


Analysis of animal models of vertigo based on the characteristics of clinical conditions in Chinese and Western medicines
Author:
Affiliation:

School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    目的 基于眩晕的中西医临床病症特点,对其现有动物模型进行分类分析,评估模型的临床吻合情况及其优缺点,以期改进现有的动物模型、为临床研究提供更直观的参考。 方法 检索数据库中从 2000 年 1 月 ~2023 年 3 月的眩晕动物模型资料,根据造模方法进行分类、结合眩晕的中西医临床病症特点和现有的动物模型评价方法,对各模型进行赋值,评估其临床吻合情况、评价模型优缺点。 结果 现有的眩晕动物模型有颈部手术模型、运动刺激模型、耳源性刺激模型、硬化剂注射模型、飞行变压模型、椎动脉结扎模型、瘀血注射模型;其中,西医吻合度较高的是颈部手术模型(65%)、耳源刺激模型(65%),所有模型中医吻合度均中等(50% ≤ 吻合度 < 60%)或较低(吻合度 < 50%),没有中、西医吻合度同时较高的模型。 结论 目前眩晕动物模型以西医疾病模型为主,缺乏中医证型模型,中、西医临床吻合度均较高的模型较少,未能突出中医药辨证论治的特色。 因此,构建出与中西医临床病症特点紧密结合的眩晕动物模型,可为抗眩晕新药的研发、筛选、临床评价提供更合理更全面的实验支撑。

    Abstract:

    Objective To classify and analyze the existing animal models of vertigo based on the clinical characteristics of Chinese and Western medicines, evaluate the clinical fit of the models, and their advantages and disadvantages, to improve the existing animal models and provide a more intuitive reference for clinical research. Methods The existing animal models of vertigo in the database from January 2000 to March 2023 were searched, and the models were classified by the modeling method combined with the characteristics of Chinese and Western medicine clinical conditions of vertigo and the existing animal model evaluation method, and assigned values to evaluate the clinical fit and the advantages and disadvantages of the models. Results The existing animal models of vertigo were neck surgery, motor stimulation,otogenic stimulation, sclerotherapy injection, flight variation pressure, vertebral artery ligation, and stasis injection models. Among them, the Western medical fit was high for the neck surgery model (65%) and otogenic stimulation model(65%). All models had a moderate Chinese medical fit (50% ≤ fit < 60%) or low(fit < 50%) TCM anast omosis. No model had both high Chinese and Western medicines anastomosis. Conclusions The animal models of vertigo are mainly Western medicine disease models, Chinese medicine evidence models are lacking, and few models have a high clinical fit between Chinese and Western medicines, which fail to highlight the characteristics of Chinese medicine. Therefore, the establishment of animal models of vertigo that are closely integrated with the clinical characteristics of Chinese and Western medicines may provide more reasonable and comprehensive experimental support for the development, screening, and clinical evaluation of new anti-vertigo drugs.

    参考文献
    相似文献
    引证文献
引用本文

李亚青,汪小毅,王灿,苗明三.基于中西医临床病症特点的眩晕动物模型分析[J].中国比较医学杂志,2024,34(01):92~99.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2023-04-20
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2024-05-13
  • 出版日期:
防诈骗提示!请勿点击不明链接或添加个人微信。编辑部所有邮箱后缀均为@cnilas.org
关闭