乳腺癌实验动物模型的研究进展
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(1. 西北农林科技大学动物医学院,陕西杨凌 712100; 2. 徐州医科大学,听觉与平衡医学研究所,江苏徐州 221004; 3. 江苏沿海地区农业科学研究所,江苏盐城 224002; 4. 北京大学医学部,北京 100191)

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R-33

基金项目:

江苏省大学生创新创业基金(16621632,KYLX14-1455, 201610313002Z)


Research progress in experimental animal models of breast cancer
Author:
Affiliation:

(1. College of Veterinary Medicine,Northwest Agriculture and Forest University, Yangling 712100, China; 2. Institute of Audiology and Balance Science of Xuzhou Medical University, Xuzhou 221004; 3. Institute of Agricultural Sciences in Coastal Area of Jiangsu Province, Yancheng 224002; 4. Key Laboratory of Medical Immunology, Ministry of Health, Peking University Health Science Center, Beijing 100191)

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    摘要:

    乳腺癌是女性最常见的自发性恶性肿瘤,给女性健康造成了严重威胁?而对乳腺癌的相关研究及治疗方法的探索上,在一定程度上需要依赖于乳腺癌实验动物模型得以实现?理想的乳腺癌实验动物模型应与人类乳腺癌在肿瘤分子特性及生物学行为等方面存在共性,以便于研究各种乳腺癌的发病机制及治疗新药的开发?本文对5 种乳腺癌实验动物模型的研究进展进行了综述,以期为人乳腺癌的诊断和治疗提供依据?

    Abstract:

    Breast cancer is the most common spontaneous malignancy in women, causing a serious threat to women’s health. Experimental animal models have been important research tools in bringing insights into the related mechanisms of breast cancer, as well as in delivering improved therapies for the disease. To reveal the pathogenesis of various breast cancers and facilitate the development of new drugs, ideal animal models of breast cancer should share some common tumor molecular characteristics and biological behavior with that of human breast cancer. In this review, five types of experimental animal breast cancer models were included, which may provide a basis for research on diagnosis and treatment of human breast cancer.

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引用本文

李日飞,袁娜,冶冬阳,李日勇,李姚涵,左儒楠,时晰,陈强,李引乾.乳腺癌实验动物模型的研究进展[J].中国比较医学杂志,2018,28(2):113~118.

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  • 收稿日期:2017-09-07
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  • 在线发布日期: 2018-03-14
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自2024年1期开始,杂志参考文献改为中英文对照,具体格式要求可置下载中心查看!
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