普通级封闭群裸鼹鼠种群建立及其生物学特性研究进展
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国家科技支撑计划(2015BAI09B02),上海市科技创新计划(16140900100,17140900200),国家自然科学基金(31700923, 31702075)


Studies on the establishment of a closed colony of conventional naked mole-rats and their biological characters
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    摘要:

    裸鼹鼠具有抗肿瘤、耐低氧、耐疼痛、寿命长等优势特性,引起了国内外广泛关注,其实验动物化及应用推广迫在眉睫。本团队围绕裸鼹鼠实验动物化及标准化开展了系统研究。通过对裸鼹鼠繁殖、遗传、微生物及营养学的研究,克服了裸鼹鼠繁殖率低下,遗传背景不明确和携带病原微生物不明的困难,成功建立了普通级封闭群裸鼹鼠种群,现种群已繁殖至第6世代。同时对所建立种群生物学特性,如耐低氧、抗肿瘤、抗衰老等开展了系统研究,期望为相关疾病的防治提供新策略。

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    Naked mole-rats (NMR, Heterocephalus glaber) are a unique species of rodents that demonstrates high longevity tumor resistance hypoxia tolerance and pain insensitivity. These features make NMRs widely used mammalian models for biomedical research in aging, cancer, neurobiology and other fields. Their laboratory animalization and application are very important. Thus, the research group produced a systematic study on the establishment of laboratory animalization and standardization of NMRs. Through the study of reproduction, genetics, microbiology and nutrition on NMRs, the difficulties of low reproductive rate, unclear genetic background and unidentified pathogenic microorganism were overcome. The population of the ordinary closed NMRs was successfully established, and the present population had been propagated to the sixth generation. At the same time, the biological characteristics of the population have been systematically studied, such as hypoxia tolerance, anti-tumor and anti-aging, which will provide new strategies for the prevention and treatment of related diseases.

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崔淑芳.普通级封闭群裸鼹鼠种群建立及其生物学特性研究进展[J].中国实验动物学报,,().

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  • 收稿日期:2018-06-01
  • 最后修改日期:2018-06-19
  • 录用日期:2018-06-20
  • 在线发布日期: 2018-11-12
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