Olfactory working memory impairment in the transgenic mice at very early stage of Alzheimer’s disease
投稿时间:2018-05-10  修订日期:2018-05-22
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KeyWord:Alzheimer’s disease  odor span  transgenic mice  working memory
                    
AuthorInstitution
张记春 北京大学第六医院
黄庚娣 北京大学第六医院
孟雪 北京大学第六医院
田永路 北京大学前沿交叉学科研究院
于欣 北京大学第六医院
张晨 北京大学生命科学学院
王华丽 北京大学第六医院
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Abstract:
      【Abstract】 Objective To explore the characteristics of olfactory working memory in the transgenic mice at very early stage of Alzheimer’s disease (AD). Methods Nine pairs of 5-week-old male 5xFAD mice and their wild-type littermates, and 8 pairs of 9-week-old male 5xFAD and their wild-type littermates were used. The study animals underwent the odor span test after extensive training. The odor span length, the number of errors and the accuracy rate of odor discrimination were used to evaluate the olfactory working memory. Results Compared with the wild-type group, the 9-week-old transgenic mice presented significantly shorter odor span length (P<0.05), more errors (P<0.05) and lower accuracy (P<0.05) of odor discrimination. Besides, the 9-week-old transgenic mice exhibited significantly shorter odor span length than the 5-week-old transgenic mice (P<0.05). However, there were no significant differences in the odor span length, the number of errors and the accuracy between the 5-week-old transgenic and wild-type mice (P>0 0.05). Conclusions Olfactory working memory is impaired in the 9-week-old transgenic mice of 5XFAD. It suggests that the olfactory working memory impairment might be considered a sensitive indicator of early cognitive impairment in the 5XFAD mice.
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