4周爬梯抗阻训练对低氧诱导大鼠骨骼肌萎缩的影响
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国家自然科学基金项目(面上项目,重点项目,重大项目)


Effects of 4 weeks resistance training on hypoxic induced skeletal muscle atrophy in rats
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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan)

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    摘要:

    【摘要】 目的 探究抗阻训练抵抗低氧诱导骨骼肌萎缩的效果,为解决高原训练期间运动员骨骼肌丢失问题提供理论依据。方法 8周龄雄性Sprague-Dawley (SD)大鼠24只,平均体重约230g,随机分为4组:C常氧安静组、R常氧抗阻训练组、H低氧安静组、HR低氧抗阻训练组。H和HR组进入模拟海拔4000 m(12.4% 氧浓度),R和HR则进行抗阻训练,进行4周的低氧及抗阻训练干预后测试各组大鼠体成分,比目鱼肌、趾长伸肌、腓肠肌、肱二头肌的湿重和肌纤维横截面积。结果 观察到HR组瘦体重显著高于H组,H组瘦体重显著低于C组; HR组的肱二头肌湿重和肌纤维横截面积显著高于H组。结论 抗阻训练有助于预防低氧诱导骨骼肌萎缩的发生,爬梯形式的抗阻练习可刺激大鼠肱二头肌的肥大。

    Abstract:

    【Abstract】Objective This study aimed to explore the effects of resistance training on hypoxic induced skeletal muscle atrophy in rats and provide theoretical basis to solve the problem of skeletal muscle atrophy of athletes in altitude training . Methods 24 male 8-week-old SD rats (mean body weight 230g) were divided into 4 groups: Normoxia control group (C), Resistance training group (R), Hypoxia group (H) and Hypoxia Resistance training group (HR). H and HR group were placed into simulated 4000 m altitude (12.4%, O2%). Moreover, R and HR group received resistance training. After 4 weeks hypoxia and resistance training intervention, body composition, the wet weight of skeletal muscle (soleus, musculus gastrocnemius, extensor digitorum longus and musculus biceps brachii) and skeletal muscle cross-sectional area (CSA) were measured. Results The muscle mass of HR group was significantly higher than H group. The wet weight and CSA of musculus biceps brachii in HR group were also higher than H group obviously. Conclusion Resistance training can help prevent the occurrence of skeletal muscle atrophy induced by hypoxia. Resistance ladder training can stimulate the hypertrophy of biceps.

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于加倍,胡扬,李燕春,梅涛,韩天雨,白学成,付鹏宇,朱镕鑫,车欣媛.4周爬梯抗阻训练对低氧诱导大鼠骨骼肌萎缩的影响[J].中国实验动物学报,,().

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  • 收稿日期:2018-03-30
  • 最后修改日期:2018-04-21
  • 录用日期:2018-05-24
  • 在线发布日期: 2018-11-12
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