Research progress of Digestive diseases animal models using Iodoacetomide
投稿时间:2018-02-26  修订日期:2018-04-05
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KeyWord:Iodoacetomide  animal models  Chronic Gastritis  Functional DyspepsIA  Ulcerative Colitis
                             
AuthorInstitution
李建锋 广西中医药大学
谢胜 广西中医药大学第一附属医院
陈广文 广西中医药大学第一附属医院
刘礼剑 广西中医药大学第一附属医院
杨成宁 广西中医药大学第一附属医院
谢洁如 广西中医药大学第一附属医院
戴文杰 广西中医药大学第一附属医院
李娟 广西中医药大学第一附属医院
陈明冰 广西中医药大学第一附属医院
黄晓燕 广西中医药大学第一附属医院
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Abstract:
      Iodoacetomide is the alkylation reagent of cysteine and histidine in proteomics, it can inhibit protease vigor and even disappear without protein degeneration, induce cell hypoxIA, mucosal injury, anxiety and depression, can basically simulate digestive system diseases such as chronic gastritis, functional dyspepsIA, ulcerative colitis pathophysiological mechanism. So it is widely used in the establishment and research of the animal models of chronic gastritis, functional dyspepsIA and ulcerative colitis. In this paper, the mechanism and modeling methods of the animal models of digestive system diseases are summarized as follows.
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