Iodoacetomide is the alkylation reagent of cysteine and histidine in proteomics, it can inhibit protease vigor and even disappear without protein degeneration, induce cell hypoxIA, mucosal injury, anxiety and depression, can basically simulate digestive system diseases such as chronic gastritis, functional dyspepsIA, ulcerative colitis pathophysiological mechanism. So it is widely used in the establishment and research of the animal models of chronic gastritis, functional dyspepsIA and ulcerative colitis. In this paper, the mechanism and modeling methods of the animal models of digestive system diseases are summarized as follows.