肾纤维化动物模型特点与研究进展
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国家自然科学基金项目(面上项目,重点项目,重大项目)


Research progress on animal models of renal fibrosis and their characteristics
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The National Natural Science Foundation of China (General Program, Key Program, Major Research Plan);The National High Technology Research and Development Program of China (863 Program);The National Basic Research Program of China (973 Program)

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    摘要:

    肾脏纤维化为慢性肾病发展至终末期肾衰所必经的相同病理路径,病理改变分为肾间质纤维化和肾小球硬化。肾脏纤维化的理想动物模型对慢性肾病发病机制的研究及其治疗药物的研发等存在现实意义。目前,肾纤维化动物模型制作包括药物或毒物诱导、手术模型以及基因敲除等多种模型,不同动物模型肾功能、肾组织病理等方面各具特点,尚无法完全模拟人类慢性肾脏疾病,这提示慢性肾脏疾病发病的复杂性,对于其病理机制认识与防治具有重要意义。

    Abstract:

    Renal fibrosis is a common pathological pathway of chronic kidney diseases that leads to end-stage renal failure. The pathological changes include glomerulosclerosis and renal interstitial fibrosis. Ideal animal models for the study of the pathologic mechanisms and drug development of chronic kidney disease are of great significance. At present, the animal models include drug or toxin induction, surgical models and gene knockout, et al. Different animal models have various characters on the renal function and pathology, but can not completely simulate human chronic kidney disease, suggests that the complexity of chronic kidney disease. So the research is important for understanding the pathological mechanisms, prevention and treatment of renal fibrosis.

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马园园,刘成海,陶艳艳.肾纤维化动物模型特点与研究进展[J].中国实验动物学报,,().

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  • 收稿日期:2017-12-25
  • 最后修改日期:2018-03-09
  • 录用日期:2018-05-10
  • 在线发布日期: 2018-11-12
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