Research progress on animal models of renal fibrosis and their characteristics
投稿时间:2017-12-25  修订日期:2018-03-09
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KeyWord:Renal fibrosis  renal interstitial fibrosis  glomerulosclerosis  animal model
马园园 上海中医药大学附属曙光医院
刘成海 上海中医药大学附属曙光医院 肝病研究所
陶艳艳 上海中医药大学附属曙光医院 肝病研究所
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      Renal fibrosis is a common pathological pathway of chronic kidney diseases that leads to end-stage renal failure. The pathological changes include glomerulosclerosis and renal interstitial fibrosis. Ideal animal models for the study of the pathologic mechanisms and drug development of chronic kidney disease are of great significance. At present, the animal models include drug or toxin induction, surgical models and gene knockout, et al. Different animal models have various characters on the renal function and pathology, but can not completely simulate human chronic kidney disease, suggests that the complexity of chronic kidney disease. So the research is important for understanding the pathological mechanisms, prevention and treatment of renal fibrosis.
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