Evaluation strategy of patient-derived xenograft models based on drug-screening of individualized treatment
投稿时间:2017-11-17  修订日期:2017-12-18
查看全文  查看/发表评论  下载PDF阅读器
DOI:
KeyWord:patient-derived xenograft models  traceability  toxicity  therapeutic evaluation
  
AuthorInstitution
张贺 沈阳军区总医院医务部
摘要点击次数: 1304
全文下载次数: 437
Abstract:
      Patient-derived xenograft (PDX) models have high consistency with their primary tumors in terms of genetics, pathology, and biological characteristics. Being perfect clinical response to the drug, this model shows a good prospect in tumor individualized treatment. It can be used to screen tumor target drug and guide clinical medication effectively. In this review, we focused on the evaluation strategy of PDX models based on chemotherapeutics screening, summarized the standards and quality control requirements of PDX model. We proposed four different ways to evaluate the traceability of models, including histomorphology detection, sequencing analysis, tumor specific markers determination and STR testing. Furthermore, chemotherapeutics effect can be evaluated by measure of drug toxicity, gauge tumor volume and establishment of TGD mathematical model. All of these methods applicated in the PDX models provide perfect strategy for guiding tumor individualized treatment.
关闭
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=D700F206953109B375880D67A7861F320DED56975D498BC1A414DE829504FB7FA1F5F1DE62DF8CEA8115F3F6F638E016BFB3785D8BF1E4E47971942466CF077442FFBB63C1E8C03E034C5B60C4FF81C1ACC658A7A1E778EF6864B392C70EC378E32B753E794F939D20BFDF9C6F4BAA0E&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=BB33F1C95224820A&jid=088025E58870DD9ABA68BCCEE1FFFF88&yid=&aid=&vid=&iid=&sid=&eid=&fileno=XB2017840&flag=1&is_more=0"> var my_pcid="A9DB1C13C87CE289EA38239A9433C9DC"; var my_cid="BB33F1C95224820A"; var my_jid="088025E58870DD9ABA68BCCEE1FFFF88"; var my_yid=""; var my_aid="";