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| The effects of rehabilitative training on motor function recovery and cAMP-protein kinase A signal transduction pathway in rats with ischemic stroke |
| Received:July 09, 2013 Revised:August 06, 2013 |
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| DOI： |
| KeyWord:Cerebral ischemia ；Rehabilitative training； cAMP-PKA |
| Author | Institution |
| 张燕虹 |
重庆医科大学 |
| 李长清 |
重庆医科大学附属第二医院 |
| 牛陵川 |
重庆医科大学附属第二医院 |
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| Abstract: |
| Objective :To observe the effects of rehabilitative training on cAMP and PKA expression, motor function in cerebral ischemia-reperfusion rats, for explore its mechanisms. Methods:The middle cerebral artery ischemia-reperfusion model was established by suture-embolus method in rats. 42 rats were randomly assigned to ischemia group, rehabilitative group and group. The changes of cAMP and PKA expression were determined by enzyme-linked immunosorbent assay (ELISA). Behavioral recovery was quantitated by scores. Results :（1）The expression of cAMP and PKA showed significant higher in rehabilitative group than the ischemia group.（2）The motor functional recovery of rehabilitative group was significantly better than the ischemia group . Conclusion: Rehabilitative training promote motor function recovery in cerebral ischemia-reperfusion rats that it was concerned with cAMP-protein kinase A signal pathway. |
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