The effects of rehabilitative training on motor function recovery and cAMP-protein kinase A signal transduction pathway in rats with ischemic stroke
Received:July 09, 2013  Revised:August 06, 2013
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KeyWord:Cerebral ischemia ;Rehabilitative training; cAMP-PKA
张燕虹 重庆医科大学
李长清 重庆医科大学附属第二医院
牛陵川 重庆医科大学附属第二医院
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      Objective :To observe the effects of rehabilitative training on cAMP and PKA expression, motor function in cerebral ischemia-reperfusion rats, for explore its mechanisms. Methods:The middle cerebral artery ischemia-reperfusion model was established by suture-embolus method in rats. 42 rats were randomly assigned to ischemia group, rehabilitative group and group. The changes of cAMP and PKA expression were determined by enzyme-linked immunosorbent assay (ELISA). Behavioral recovery was quantitated by scores. Results :(1)The expression of cAMP and PKA showed significant higher in rehabilitative group than the ischemia group.(2)The motor functional recovery of rehabilitative group was significantly better than the ischemia group . Conclusion: Rehabilitative training promote motor function recovery in cerebral ischemia-reperfusion rats that it was concerned with cAMP-protein kinase A signal pathway.
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