Ischemic postconditioning attenuates lung ischemia-reperfusion injury by hemeoxygenase-1 induced STAT-3 activation in rats
Received:June 25, 2013  Revised:June 25, 2013
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KeyWord:hemeoxygenase-1; ischemic postconditioning; ischemia reperfusion injury; STAT-3
徐波 首都医科大学附属北京友谊医院
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      To study the mechanisms of hemeoxygenase-1 (HO-1) in ischemic postconditioning attenuating lung ischemia reperfusion injury and its effects on STAT-3 in postischemic lung of rats. Methods: Forty male SD rats were randomly assigned to shame group (S), ischemia-reperfusion injury group (IR), ischemic postconditioning group (IPO) and IPO with HO-1 inhibitor ZnPP treatment group (IPO ZnPP). The ratio of dry / wet weight (W/D), the level of MDA, and the activity of MPO and HO-1 were measured in postischemic lung tissures. The protein expression of HO-1 and p-STAT-3 were detected by Western blot. Results: The levels of W/D, MDA, MPO, HO-1 activity and its protein expression were all significantly increased as compared with the S group, while the expression level of p-STAT-3 protein was significantly decreased, IPO can reverse these changes, and the specific inhibitor of HO-1 Znpp canceled the effects of IPO on the above indexes. Conclusion: IPO attenuates lung ischemia-reperfusion injury by promoting HO-1 induced activation of STAT-3 signaling pathway.
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