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| The effects of overexpressed mice UNCV protein on apoptosis in Hela cells |
| Received:April 15, 2013 Revised:May 22, 2013 |
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| DOI： |
| KeyWord:UNCV; apoptosis; serum starvation; doxorubicin |
| Author | Institution |
| 刘冰 |
军事医学科学院实验动物中心 |
| 徐嫄 |
军事医学科学院实验动物中心 |
| 赵爽 |
军事医学科学院实验动物中心 |
| 王冬平 |
军事医学科学院实验动物中心 |
| 杨蕾蕾 |
军事医学科学院放射与辐射医学研究所 |
| 李微 |
军事医学科学院实验动物中心 |
| 尚世臣 |
军事医学科学院实验动物中心 |
| 张广州 |
军事医学科学院实验动物中心 |
| 李文龙 |
军事医学科学院实验动物中心 |
| 曾林 |
军事医学科学院实验动物中心 |
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| Abstract: |
| Objective To study the effects of the mice UNCV protein on Hela cells apoptosis. Methods The recombinant plasmids containing Uncv gene of BALB/C mice were transfected into Hela cells. The Hela cells which stably overexpressed UNCV protein were selected. The effects of overexpressed UNCV protein on apoptosis of Hela cells induced by doxorubicin and serum starvation were measured by cell counting and flow cytometry. Results The Hela cells which stably overexpressed UNCV protein were obtained. The results of cell counting and flow cytometry showed that overexpression of the UNCV protein inhibited apoptosis of Hela cells induced by serum starvation. The effects of UNCV protein on apoptosis of Hela cells induced by doxorubicin were not significantly different. Conclusions Overexpression of UNCV protein inhibited apoptosis of Hela cells induced by serum starvation. |
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