Objective To observe the effect of curcumin on the status of cerebral glucose metabolism in 9 months APP /PS1 double transgenic mice by 18F-FDG Micro PET．Methods Nine-month-old APP /PS1 dtgmice were randomly chose from the model group，the positive Rosiglitazone control group and curcumin high(400 mg/kg?d),medium(200 mg/kg?d)and low(100 mg/kg?d)dose group，with normal C57BL /6J mice with the same background randomly selected( age: 9 months; n= 3) for Micro PET study．Each mouse was anesthetized using 2% isoflurane and was injected through a tail vein with 14.8-16.5 MBq 18F-FDG as a bolus． After 1 hour of 18F-FDG uptake period，PET scans were performed for 10-min． Calculate and compare 18F-FDG uptake rate per gram tissue of the whole brain ( except cerebellum) in the mice of different groups． Results Cerebral 18F-FDG uptake rate per gram tissue of curcumin medium dose group mice and the positive Rosiglitazone control group is higher than both the normal control group and model group mice．Conclusions Curcumin can increase APP /PS1 dtgmice cerebral 18F-FDG uptake and 18F-FDG uptake rate per gram tissue． Curcumin may play a neuroprotective role through improving cerebral glucose metabolism.