PURPOSE: To investigate CT perfusion features in C6 rat gliomas, and analyze correlations between perfusion CT paremeters and CD105-MVD. MATERIALS AND METHODS: Total 20 male SD rats, weighting 250-300g, were divided into glioma group (n=10) and control group (n=10) at random. Rats in glioma group were implanted C6 glioma cells at right caudate nucleus of rat brain through stereotaxic apparatus to establish a rat brain glioma model. After three weeks, perfusion CT was performed in glioma group and control group. Perfusion CT values (CBV, CBF, PS and MTT) were measured at the right nucleus caudatus in rat brain tissue. The rats were killed and their brains were removed within 24 hours after perfusion CT, the samples at nucleus caudatus in rat brain tissue were examined histologically using HE and immunohistochemical staining for FⅧ and CD105. The differences between the number of FⅧ positively staining vessels within gliomas and that of normal brain tissues in control group were determined using independent samples t test. Pearson correlation coefficients were used to investigate relationships between perfusion CT parameters (CBV, CBF, PS and MTT) and immunohistochemical parameters (FⅧ-MVD and CD105-MVD). RESULTS: All rat brain gliomas, three weeks after C6 glioma cells implanted, were viewed as significantly enhanced mass on contrast enhancement CT scan. Control group rat brain CBV, CBF, PS and MTT values (mean ?SD) were (10.28?.01) mL/100g, (304.95?8.77) mL/100g.min, (0.26?.34) mL/100g.min, (1.48?.07) s, respectively. Rat gliomas at right caudate nucleus area CBV, CBF, PS and MTT values (mean ?SD) were (17.35?.73) mL/100g, (508.66?58.88) mL/min.100g, (13.92?.96) mL/min.100g, (1.79?.44) s, respectively. CBV, CBF and PS values in glioma group were significant higher than those in control group. FⅧ-MVD and CD105-MVD in glioma group was (34.7 vessels per field?.13) and (16.6 vessels per field?.12) respectively. Significant correlations were observed between FⅧ-MVD, CD105-MVD and CBV, PS in glioma group. CBF correlated well with the number for CD105-MVD, while CBF was not significant correlation with FⅧ-MVD in glioma group. MTT was not significant correlation with MVD in glioma group. CONCLUSION: Significant correlations between perfusion CT parameters (CBV、CBF and PS) and CD105-MVD. Perfusion CT can reflect tumoral angiogenesis in C6 rat brain gliomas.