Chronic kidney disease (CKD) is defined as a chronic structural and functional disorder of the kidney ( history of kidney damage >3 months) with various causes. CKD-associated pruritus, previously known as uremic pruritus, is a common symptom in patients with advanced CKD and end-stage renal disease worldwide, with an incidence of 28% to 70% in dialysis patients. Pruritus can cause skin damage and sleep disturbances, which can in turn seriously affect patient quality of life and sleep quality, and may even lead to depression and suicidal tendencies. There is thus an urgent need to investigate the pathogenesis of and develop new treatments for CKD-associated pruritus. However, animal models of CKD- associated pruritus are rare, and a reliable and effective animal model is urgently required. In this paper, we review the etiopathology of CKD-associated pruritus, consider chronic pruritus models, and assess pruritus behavior in animals.