Advances in animal models of pruritus associated with chronic kidney disease
Received:September 07, 2021  
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DOI:10. 3969 / j.issn.1005-4847. 2022. 03. 019
KeyWord:chronic kidney disease-associated pruritus; uremia-associated pruritus; animal model
韩壤乐 西南医科大学附属中医医院中西医结合研究中心,四川 泸州
胡琼丹 1. 西南医科大学附属中医医院中西医结合研究中心,四川 泸州 ;2. 西南医科大学附属中医医院肾病内科, 四川 泸州
王丽 西南医科大学附属中医医院中西医结合研究中心,四川 泸州
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      Chronic kidney disease (CKD) is defined as a chronic structural and functional disorder of the kidney ( history of kidney damage >3 months) with various causes. CKD-associated pruritus, previously known as uremic pruritus, is a common symptom in patients with advanced CKD and end-stage renal disease worldwide, with an incidence of 28% to 70% in dialysis patients. Pruritus can cause skin damage and sleep disturbances, which can in turn seriously affect patient quality of life and sleep quality, and may even lead to depression and suicidal tendencies. There is thus an urgent need to investigate the pathogenesis of and develop new treatments for CKD-associated pruritus. However, animal models of CKD- associated pruritus are rare, and a reliable and effective animal model is urgently required. In this paper, we review the etiopathology of CKD-associated pruritus, consider chronic pruritus models, and assess pruritus behavior in animals.
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