Functional dyspepsia (FD) is a common and recurring disease, which is difficult to treat so it becomes a refractory disease. Because of the unknown etiology of FD, the current modeling method used in animal research remain controversial. The lasting effect of animal models provides an important reference value for potential treatments of FD. However, no article has comprehensively summarized the lasting effect of existing animal models of FD. To provide a reliable reference for establishing an FD animal model, we classify each model as sustained type and temporary type based on its lasting effect.