Effects of different body weights on the progression of abdominal aortic aneurysm in chow diet feeding mice: a retrospective study
Received:August 21, 2021  
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DOI:10. 3969 / j.issn.1005-4847. 2022. 01. 007
KeyWord:body weight; abdominal aortic aneurysm; porcine pancreatic elastase; immunochemistry
刘懿 西安交通大学医学部实验动物中心,西安
田康利 西安交通大学医学部实验动物中心,西安
夏聪聪 西安交通大学医学部实验动物中心,西安
刘浩乐 西安交通大学医学部实验动物中心,西安
付维来 天津医科大学第二医院血管外科,天津
许杨威 西安交通大学医学部实验动物中心,西安
白亮 西安交通大学医学部实验动物中心,西安
刘恩岐 西安交通大学医学部实验动物中心,西安
赵四海 西安交通大学医学部实验动物中心,西安
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       Objective This study aimed to analyze the effect of preoperative body weight on the progression of porcine pancreatic elastase (PPE)-induced abdominal aortic aneurysm (AAA) in mice fed a normal diet. Methods We retrospectively analyzed the association of preoperative body weight and postoperative abdominal aortic diameter in 44 PPE- induced abdominal aortic aneurysm mouse models in our laboratory. Sixteen mice, divided into group 1 (n= 8, preoperative weight less than 25 g) and group 2 (n= 8, preoperative weight of more than 30 g) were chosen for the following analysis. The body weight, fat distribution, abdominal aorta diameter and diameter changes of all mice were analyzed. Comparative analysis of histology and immunohistochemistry of AAA lesions was conducted among group 1, group 2 and normal control animals. The normal control mice were free of surgery. Results The correlation coefficient between the aortic diameter and preoperative body weight was 0. 005 (using the 44 included mice). No significant influence of body weight was found on the progression of AAA in mice fed a normal diet in this study. Further analysis found that there were no significant differences in the abdominal aortic diameter (1. 35 mm vs 1. 27 mm) and diameter changes (0. 85 mm vs 0. 72 mm) between the model groups 1 and 2 at day 14 after the surgery. Compared with normal control mice, PPE-treated mice in model groups 1 and 2 had a significant increase in the diameter of the infrarenal aorta at postoperative day 14, and all formed aneurysms. Histological observations showed typical AAA lesion features, such as elastic fiber breakage, smooth muscle exhaustion, increased inflammation and abnormal angiogenesis. Conclusions Body weight was not associated with the progression of PPE-induced AAA in mice fed a normal diet.
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