Advances in the study of animal models of type Ⅱ cardiorenal syndrome
Received:January 14, 2021  
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DOI:10. 3969 / j.issn.1005-4847. 2021. 04. 016
KeyWord:cardiorenal syndrome; animal model; cardiac function; renal function
查玉玲 1.中国中医科学院广安门医院,北京 ; 2. 北京中医药大学,北京
孔淼 中国中医科学院广安门医院,北京
周育平 中国中医科学院广安门医院,北京
张文杰 1.中国中医科学院广安门医院,北京 ; 2. 北京中医药大学,北京
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      Cardiorenal syndrome (CRS) is the end-stage form of heart and kidney disease and it is associated with a poor outcome. Further study of the physiological and pathological mechanisms of CRS is still required to facilitate improvements in treatment. Therefore, it is important to establish appropriate animal models that simulate the features of the pathogenesis of the disease in humans. In this article, we have reviewed and evaluated the clinical relevance of animal models of type II CRS on the basis of a search of the international literature. We discuss simple animal models, which include coronary artery ligation, aortic constriction, spontaneous hypertension, drug administration, arteriovenous fistula, and transgenic mouse models; and composite models, including coronary artery ligation combined with nephrectomy, and nephrectomy combined with drug administration.
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