Establishment of a rat colorectal distension-induced model of visceral hypersensitivity
Received:December 30, 2020  
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DOI:10. 3969 / j.issn.1005-4847. 2021. 04. 015
KeyWord:irritable bowel syndrome(IBS); colorectal distension(CRD); visceral hypersensitivity; animal model
蒋慧灵 成都中医药大学针灸推拿学院,成都
郑倩华 成都中医药大学针灸推拿学院,成都
赵映 成都中医药大学针灸推拿学院,成都
张薇 成都中医药大学针灸推拿学院,成都
侯雨君 成都中医药大学针灸推拿学院,成都
谭玉 成都中医药大学针灸推拿学院,成都
李瑛 成都中医药大学研究生院,成都
蔡定均 成都中医药大学针灸推拿学院,成都
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      Irritable bowel syndrome ( IBS) is a common intestinal disease characterized by recurrent abdominal pain and changes in the feces and / or defecatory habits. However, although the etiology and pathogenesis of IBS remain unclear, visceral hypersensitivity is widely accepted to be an important pathogenetic factor. Therefore, it is important to be able to study an appropriate animal model of visceral hypersensitivity. Colorectal distension (CRD) is widely used for this purpose because it induces persistent and stable visceral hypersensitivity through continuous mechanical stimulation that is not associated with obvious pathological changes in the rectum, which is consistent with the pathological characteristics of IBS. In the present paper, we discuss the surgical procedure, the limitations of CRD, the various experimental devices and expansion method used, and other related factors in order to provide a reference for researchers who wish to use CRD-based models of visceral hypersensitivity.
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