Differences in the effects of dietary lipids on the physiology and biochemistry of mice
Received:December 23, 2020  
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DOI:10. 3969 / j.issn.1005-4847. 2021. 04. 010
KeyWord:Feed model; dietary fat; recommended dietary oil energy level; low-fat diet; recommended oil intake level
                       
AuthorInstitution
李鑫 湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙
张琳玉 湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙
王湘林 湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙
刘翔燕 湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙
李晓文 湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙
王吉 湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙
文利新 1.湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙 ; 2. 湖南畜禽安全生产协同创新中心,长沙
周迎芳 1.湖南农业大学动物医学院畜禽保健湖南省工程研究中心,长沙 ;3. 湖南农业大学东方科技学院,长沙
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Abstract:
       Objective To compare the effects of dietary oil content on the physiology and biochemistry of mice to provide a basis for the selection of appropriate oils for inclusion in animal feeds and for human health. Methods Two levels of dietary energy supply from oils were tested in male C57BL/ 6J mice: a 20% ( low-oil energy supply) and 30% (high-oil energy supply), based on the recommendation that dietary energy supply in lipid form should not exceed 30%. Furthermore, each energy supply level was provided as lard (LA), rapeseed oil (RA), olive oil (OL), or a lard and rapeseed blend oil (mass ratio 1 ∶ 1) (BO). After 16 weeks of feeding, the mice’ s growth performance, fat deposition, serum biochemical indices, and blood glucose concentrations were compared. Results Low-OL diet feeding was associated with lower body mass and accumulation of perirenal and epididymal fat (P< 0. 01). High-OL and high-RA feeding were also associated with lower body mass and accumulation of perirenal and epididymal fat (P< 0. 01). The liver index of both the low-OL and high-OL groups was very high (P< 0. 01), and the kidney index was high in the low-RA group (P< 0. 05) and in the high-LA and high-RA groups (P< 0. 01). The circulating total cholesterol content of the high-RA group was significantly lower than that of the other groups (P< 0. 05), and the triglyceride concentration of the high-OL group was the lowest. The high-density / low-density lipoprotein-cholesterol was significantly higher in the low-RA groups than in the other three low-oil energy supply groups (P< 0. 05), but there was no difference between the high-RA and high-OL groups. Glucose and insulin tolerance testing showed that the low-BO and low-OL groups had superior glucose homeostasis to the other low-oil energy supply groups, but there were no significant differences between the four high-oil energy supply groups, and although the final blood glucose concentration in the BO group was slightly higher, there was no difference in the area under the curve. Conclusions A large amount of dietary lard or a lard / rapeseed oil 1 ∶ 1 blend increases body mass and fat deposition in mice. In contrast, both low and high levels of energy provided as olive oil reduce weight gain and fat deposition, but may have deleterious effects on the liver. Feeding of rapeseed oil is preferable for blood lipid profile but may have deleterious effects on the kidney. None of the four kinds of oil had deleterious effects on glucose homeostasis in mice.
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