Traditional Chinese medicine (TCM) syndrome models have only recently been explored. To promote the modernization of TCM, in-depth research, and discussion of TCM syndrome, animal models are required. As a common syndrome type of cardiovascular disease, the establishment of an animal model of qi deficiency and blood stasis syndrome is a hot issue in the experimental study of TCM syndrome. Through research on various animal models of heart qi deficiency and blood stasis syndrome, the macroscopic signs, echocardiography, hemodynamics, and other indicators of experimental animals were observed, and the modeling method were Objective ly evaluated. At the same time, the current animal model of TCM syndrome was proposed. The existing problems in the study and prospects of heart qi deficiency and blood stasis syndrome clinical treatment could be addressed by the development of new models.