Research progress on animal models of nonalcoholic steatohepatitis
Received:June 30, 2020  
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DOI:10. 3969 / j.issn.1005-4847. 2021. 01. 019
KeyWord:nonalcoholic steatohepatitis(NASH); animal model; metabolic syndrome
     
AuthorInstitution
蔡江帆 浙江中医药大学生命科学学院,杭州
陈民利 浙江中医药大学实验动物研究中心/ 比较医学研究所,杭州
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Abstract:
      With the increasing global prevalence of metabolic syndrome, the prevalence of non-alcoholic fatty liver disease (NAFLD) has also risen sharply. NAFLD is the most common chronic liver disease in the world and includes simple steatosis and non-alcoholic fatty hepatitis ( NASH), advanced fibrosis, cirrhosis and hepatocellular carcinoma. NASH is an important stage from simple steatosis to fibrosis, cirrhosis and liver cancer. Therefore, the prevention and treatment of NASH has become an important research focus. Animal models are critical tools for studying the pathogenesis of diseases, research and development of therapeutic drugs, and formulating prevention and treatment strategies. The animal models that have been developed so far for NASH mainly simulate the pathological morphology and clinical characteristics of human NASH. These models include dietary animal models, drug-induced animal models and genetically modified animal models, and each model has its own advantages and disadvantages. In this paper, we review the research and applications of NASH animal models for NASH research.
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