Research and development of in vivo detection technology for calcium signals in model animal neurons
Received:June 25, 2020  
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DOI:10. 3969 / j.issn.1005-4847. 2021. 01. 015
KeyWord:calcium signals; two-photon calcium imaging; deep brain microscopic calcium imaging; fiber recording technology
           
AuthorInstitution
李谦 1.山东中医药大学,济南 ; 2. 山东中医药大学附属眼科医院,济南 ; 3. 山东省中西医结合眼病防治重点实验室,济南 ; 4. 山东中医药大学眼科研究所,济南
毕爱玲 1.山东中医药大学,济南 ; 2. 山东中医药大学附属眼科医院,济南 ; 3. 山东省中西医结合眼病防治重点实验室,济南 ; 4. 山东中医药大学眼科研究所,济南
王兴荣 1.山东中医药大学,济南 ; 2. 山东中医药大学附属眼科医院,济南 ; 3. 山东省中西医结合眼病防治重点实验室,济南 ; 4. 山东中医药大学眼科研究所,济南
毕宏生 1.山东中医药大学,济南 ; 2. 山东中医药大学附属眼科医院,济南 ; 3. 山东省中西医结合眼病防治重点实验室,济南 ; 4. 山东中医药大学眼科研究所,济南
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Abstract:
      Calcium is an important messenger in mammalian nerve cells. It mediates a variety of intracellular signal transduction pathways and plays an important role in regulating neuronal functions. Calcium signaling performs its highly specific functions in a defined subregion of the cell, especially in the cortex. Detection of calcium signals in neurons is particularly important to study neuronal functions. In this article, we review the method of detecting calcium signals in model animals. The common method include two-photon calcium imaging technology, deep brain microscopic calcium imaging technology, and optical fiber recording technology. Through a literature review and analysis, new developments in this field are presented. We also discuss the prospects of calcium signal detection to study cortical neuronal signals and plasticity in various animal models.
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