Advances in the establishment and evaluation of animal models of primary headache
Received:April 13, 2020  
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DOI:10. 3969 / j.issn.1005-4847. 2020. 05. 020
KeyWord:primary headache; migraine headache; tension type headache; animal models; establishment Methods; evaluation Methods Conflicts of Interest: The authors declare no conflict of interest.
叶淑姿 中南大学湘雅公共卫生学院卫生毒理学系,长沙
肖芳 中南大学湘雅公共卫生学院卫生毒理学系,长沙
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      Primary headache is a condition with a high disability rate, particular in young adults. It not only brings suffering to the patients but also places a heavy burden on society. However, the pathogenesis of primary headache is still unclear. The establishment of reliable animal models of primary headache is helpful to explore the pathogenesis and develop drugs for prevention and treatment. Here, we comprehensively summarize animal models of primary headache in recent years from the perspectives of animal model principles, Methods evaluations, scope of application, and advantages and disadvantages.
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