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| Advances in murine models for food allergies |
| Received:February 10, 2020 |
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| DOI：10. 3969 / j.issn.1005-4847. 2020. 04. 020 |
| KeyWord:food allergy; mouse model; genetic engineering model; humanized mouse |
| Author | Institution |
| 王峥 |
河南中医药大学,中医药科学院,郑州 |
| 李秀敏 |
纽约医学院,微生物与免疫学系,耳鼻喉系,纽约 10595 |
| 苗晋鑫 |
河南中医药大学,中医药科学院,郑州 |
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| Abstract: |
| Food allergies are rapidly becoming a global health problem. Food allergic reactions are caused by Th2 responses to harmless foods, leading to IgE-mediated mast cell degranulation and related inflammatory responses. Food allergy murine models are helpful for studying the pathology, physiology and new treatment strategies for human food allergies. These models can be divided into adjuvant-dependent, adjuvant-free, genetic-engineered and humanized mouse models. However, no animal models can reproduce the entire range of human pathological features; therefore, specific mouse models of food allergies must be used to address specific food allergy research issues. This article summarizes the literature, research progress on modeling method, and advantages and disadvantages of different murine models of food allergies over the last 20 years and provides a reference and scientific basis for researching food allergy mechanisms and developing new treatment method . |
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