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| Research progress on the characteristics of animal models of chronic obstructive pulmonary disease and related clinical applications |
| Received:December 23, 2019 |
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| DOI：10. 3969 / j.issn.1005-4847. 2020. 04. 019 |
| KeyWord:chronic obstructive pulmonary disease; COPD animal model; model characteristics and application |
| Author | Institution |
| 陈美凤 |
沈阳医学院,沈阳医学院附属中心医院,呼吸与危重症医学,沈阳 |
| 加慧 |
沈阳医学院,沈阳医学院附属中心医院,呼吸与危重症医学,沈阳 |
| 夏书月 |
沈阳医学院,沈阳医学院附属中心医院,呼吸与危重症医学,沈阳 |
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| Abstract: |
| Chronic obstructive pulmonary disease ( COPD) is characterized by incomplete reversible persistent progressive airflow limitations, and always presents acute exacerbations and serious complications. Establishing standardized animal models that are consistent with the clinical COPD characteristics of COPD is important for exploring its development, and morphological changes, as well as new therapeutic approaches. new therapeutic approaches. Many studies have been conducted on COPD, but there is no best method exists for constructing animal models of COPD. Here, we describe and compare the types of animals used to establish the COPD models and the advantages, and disadvantages, and clinical applications of each model. |
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