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| Research progress in the establishment of animal models of acute spinal cord injury |
| Received:February 09, 2020 |
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| DOI：10. 3969 / j.issn.1005-4847. 2020. 04. 017 |
| KeyWord:Acute spinal cord injury; animal model; mechanical injury |
| Author | Institution |
| 刘海峰 |
1.山西医科大学第二医院骨科,太原 ; 2. 骨与软组织损伤修复山西省重点实验室,太原 |
| 王斌 |
1.山西医科大学第二医院骨科,太原 ; 2. 骨与软组织损伤修复山西省重点实验室,太原 |
| 赵斌 |
1.山西医科大学第二医院骨科,太原 ; 2. 骨与软组织损伤修复山西省重点实验室,太原 |
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| Abstract: |
| Acute spinal cord injury is a central nervous system injury with a high disability rate and serious consequences, which brings a heavy burden to individuals, families and society. No effective treatments exist for spinal cord injuries, but different therapies, including stem cells, drugs and tissue engineering have been used in various animal models with some success. Similar questions remain as to whether the mechanism of injury, effectiveness, and integrity of animal models can mimic what is seen clinically. This paper describes the application, advantages, and disadvantages of several common animal models of acute mechanical spinal cord injury, as well as the selection of common animal types and injury segments, to provide references for selecting more effective animal models. |
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